In Eswatini we provide technical assistance and capacity building to community, facility, regional, and national health structures, and services to optimize effective, patient-centered, and high-quality HIV/TB services to foster sustained control of the HIV and TB epidemics and limit the impact of emerging public health threats like COVID-19 on HIV and TB programs. We also support expanding evidence-based community HIV and gender-based violence prevention and response interventions for vulnerable and at-risk populations in targeted geographic areas. These efforts particularly target adolescent girls and young women, adolescent boys and young men, HIV-exposed infants and their mothers, and children of index HIV and TB patients. Further, we provide technical assistance designed to integrate community voices into the planning and rollout of local, culturally appropriate health interventions and reach at-risk populations not served with conventional strategies, expand engagement at the community level, and support linkages to the formal health system and to decision makers throughout the system up to sub-national and national political leaders. We also support the Ministry of Health in strengthening integration of HPV and COVID-19 vaccination into routine service delivery under the Expanded Program on Immunization in two regions of the country, including micro-planning, service delivery efforts and community outreaches. In addition, we provide intensive capacity building at national, regional, and facility levels to institutionalize Data Use and Continuous Quality Improvement to sustain program gains and promote local ownership of TB/HIV service delivery by the MoH.